I know others will be interested to see the numbers. I might make a list for number of appearances in video games too later.
Top 25 (as of the moment) female character from Marvel and Dc with most number of appearances according to Comic Vine ( links above_
1. Storm - 7,778 appearances ( First appearance, May 1975 )
2. Jean Grey - 5,992 appearances ( First appearance, September 1963 )
3.
Wonder Woman - 5,914 appearances ( First appearance, 1941 )
4. Rogue - 5,255 appearances ( First appearance, 1981 )
5. Invisible Woman - 5,105 appearances ( First appearance, 1961 )
6. Kitty Pryde - 4,932 appearances ( First appearance, January, 1980 )
7. Emma Frost - 4,841 appearances ( First appearance, January, 1980 )
8.
Lois Lane - 4,515 appearances ( First appearance, June , 1938 )
9. Psylocke - 3,588 appearances ( First appearance, December, 1976 )
10. Scarlet Witch - 3,549 appearances ( First appearance, March, 1964)
11. Carol Danvers - 3,183 appearances ( First appearance, March, 1968)
12. Wasp - 2,973 appearances ( First appearance, June , 1963 )
13. Black Widow - 2,954 appearances ( First appearance, April, 1964 )
14. Mary Jane Watson - 2,910 appearances ( First appearance, June , 1965 )
15.
Barbara Gordon - 2,523 appearances ( First appearance, January, 1967 )
16.She-Hulk - 2,424 appearances ( First appearance, February, 1980 )
17.
Black Canary - 2,365 appearances ( First appearance, August, 1947 )
18.
Supergirl - 2,336 appearances ( First appearance, May, 1959 )
19. Mystique - 2,295 appearances ( First appearance, April )
20. Magik - 2,254 appearances ( First appearance, May 1975 )
21. Aunt May - 2,245 appearances ( First appearance, August , 1962 )
22. Jubilee - 2,201 appearances ( First appearance, May, 1989 )
23.
Catwoman - 2,039 appearances ( First appearance, April, 1940 )
24.
Hawkgirl - 1,424 appearances ( First appearance, January, 1940 )
25.
Starfire - 1,403 appearances ( First appearance, October, 1980 )
Ororo Munroe aka Storm takes the top spot by a large margin even if there are a lot of female characters who first appeared in comics before her.
Only 8 ladies from DC (in blue font) are in the top 25.