There's a female Doctor Octopus already, who should have reappeared in Superior Spider-Man to avenge her beloved mentor's "death" at Spider-Man's hands, completely unaware that "Spider-Man" was her mentor all along in the stolen body of his arch-nemesis, or at any point after Superior Spider-Man was over with. I could also see her trying to reunite with the new "Superior Octopus," Otto's mind in a cloned body synthesized from his and Peter Parker's DNA and thus possessing the abilities of both. Would be even better if she tried to take over A.I.M. (super-science-enabled terrorism and crime is their mutual jam) or otherwise become a major player in the tech crime underworld as opposed to trailing in Otto's shadow.