The importance of Sinister making chimeras long before the were "supposed" to exist.
The Diary Entries, mention them losing Magneto... yet he is still there. Is that really Magneto?
I joked on a previous issue about Xavier rebooting himself when his conscience kicks in, but maybe it's something like that? Like a constant rewind to being at his most nihilist. Plus that knowledge makes it hard to believe that the X-men haven't been tampered in some form.
Something tells me that Moira & Sinister are eventually going to be revealed to be working together in some capacity