While there are a number of top tier female scientists in the DCU (many of them already mentioned in this thread), I'm not sure there are any that have been overtly portrayed in the Lex Luthor/Niles Caulder/Prof. Haley/Mr. Terrific/Dr. Sivana "Top of the Field in Every Known Field" kind of way.
There was a push to establish Veronica Cale into that rarefied realm a few years back, but getting it to stick has been difficult.
Personally, I think Marvel's done a better job on this front.