I doubt they would ever kill Gwen off, but if they did it would probably be with a plan to clone her.
You say that like it's a bad thing .
Although I'll be surprised if Anna Maria doesn't show up around the time they adapt Superior. They'd probably give Ock his love story before they ever give Peter one on this sow.
I don't think seeing these characters actively get involved in these dangerous situations is necessary to prove they have back-bones, especially if it comes at Spidey's expense that he needs to get bailed out like that.
I'm not even sure if we should really view these characters as "regular civilians" since they're all super-geniuses going to a super-science school who will inevitably all don costumes at some point. The only actual regular person on this show seems to be Aunt May.