Dr. Doom regularly loses to the F4 then turns around and takes on characters like the Beyonder, his sorcery and science shouldn't allow him to do things like that yet he does. Unless Blade is taking on Thanos level villains I don't see why he absolutely needs powers. If he's facing barely superhuman characters not much stronger than Cap it's not like he'll die without powers.
I see the majority of Blade fans here want him with powers tho so it doesn't matter what I think agree to disagree all I'll say is if a character absolutely must have powers that makes them seem less interesting imo. A character should be more than their powers and abilities unless it's a huge part of their character. Obviously Superman needs to be super and Hulk needs to get stronger the madder he gets but will Blade fundamentally change as a person with or without powers?