Yeah I think we've gotten to a point where nothing is really "sacred" with the character anymore.
spoilers:
We've now had two adaptations with Aunt May's death; one with Peter Parker's death and another Spider-man taking over; two with middle-aged Parkers, and several involving multiple Spider-characters coming out of the woodwork |
end of spoilers
But there's definitely a "classic" status quo that the character will always cycle back to, and MJ has been cemented as being part of that. It's just a shame that, outside of maybe Spectacular, we haven't gotten an adaptation that really embodied her personality from the comics. And I doubt we'll be getting one anytime soon.
I really hope Marvel starts doing some adult Direct-to-Video animated adaptations of their comics like DC.