To those saying Rosenberg's run will do long-time damage, I don't think we can definitively say that for about another year. We need to see what Hickman does and does not incorporate/reference before we can say how harmful the run was.
I thought Loeb's Wolverine run would destroy the character, but, while it lead to developments in Wolverine: Origins, it didn't really have much affect on anything after that book ended. Even then, that book kinda undercut what Loeb seemed to be going for in his initial run.
Still, Rosenberg's Uncanny sucked.