yeah
in many ways, Iron Man outgrew his rogues gallery, either from a tech perspective or cultural (Mandarin is such a hot potato, that he scares a lot of people whom would repackage him beyond his original "yellow peril role").
I still stand by adding both Gideon and Circuit Breaker to his rogues gallery would really help with storytelling.
hell, call Gideon an inhuman if you have to.
edit: and also, for goodness sake, start stealing the repackaging that was done in armored adventures.
Ghost, Living Laser, Rhona Burchill (and her amazing android), madame masque, Scientist Supreme, Technovore, Ivan Vanko (although I would mix a bit of the movie version's whiplash as well), and the heavy cribbing of alien tech to represent stuff like grim reaper and grey garogoyles.
Hell
Make khan the new Mandarin. They did the impossible, found an angle that makes him awesome.
the only reason Techno didn't make the cut, is he's pretty damn awesome in the thunderbolts and needs to be back alive again. .