I'm kind of reminded of the scene from HULK: THE END where Hulk was eaten by the cockroaches but still came back OK.
I haven't read the issue yet, but is Betty kind of stuck in this form permenantly? solitications for future issues seem to imply Rick might be able to change back to human, although maybe not entirely. The cover for #22-if that's him-seems to show that something's not quite right with his mouth.
Also, somebody at comicboards did make a good point about Betty and Bruce-she did actually shoot him once, eventually resulting in the creation of Doc Green.