*Throughout the entire film, when anyone else faced Thanos directly, he laid them out easily if not outright one-shot them without using the gems to enhance his might or really put any full force in his blows. Iron Man, Starlord, Drax, Spider-Man used their speed and agility to get hits in on the Mad Titan, but when he hit them, even while restrained and without the Infinity Stones for enhancement, they were laid out. He even one-shot most of them as if he were swatting insects away. He physically hit Iron Man once and it severely damaged his armor and knocked/ripped the helmet off his head. They were of no threat to him in an actual fight, with or without the Infinity Gauntlet.