Galactus empowers Kingpin as his Herald, standard cosmic power set. After about a year of excellent service, Galactus releases him and he returns home to current 616-Earth.
What happens? Does he become ruler of the world? Other than Sentry (if he's even still around), can anyone stop him?
Suppose Fisk decides accumulate all underworld power to himself, subverting all organizations, from Hydra and the Mafia to SHIELD and each nation's intelligence services?
Fisk may even have contacts in extraterrestrial criminal organizations, may seek to make Earth the crime capital of the Milky Way galaxy....
Answer for any aspect of the scenario that you find interesting.