My guess is a simple no but you never know; I think we can all agree that Hobgoblin and Venom were the last two villains to be introduced that have achieved classic/legendary status. Maybe Carnage though I think he falls just a little short. But, since then----and we are a quarter century on now, I don't think anyone has come close.
JMS made a good push with Morlun and Dan Slott with Mr. Negative but I don't think either is anywhere near the status of the aforementioned nor the classic rogues' gallery. We have had some good new additions over the last 25 or so years (Paper Doll, Fusion and Mr Negative all quickly come to mind) but it's no secret that it is hard for any writer to come up with a new big baddie that will be remembered years from now. It probably comes down to the best ideas have been mined long ago and the fanbase frankly just wants the "greatest hits" the same as most concertgoers when they buy that ticket to see U2 or Tom Petty.
Thoughts?