I'd rather something much more sadistic. Like Alpha and Dr.Poison said, Dr. Poison should be merciless and her experiments demented. I'd rather Dr. Poison created some blight in Themyscira that automatically plagues and slowly kills anyone who comes into the area. Dr. Poison is, or course, immune. Flying creatures are constantly falling from the sky, the crops are dead, the ground is rotting, the sculptures and architecture are melting. Diana is forced to fight her deceased sisters that Poison has experimented on. They are given all types of venomous abilities like exhaling poisonous gas, infectious claws, etc. Dr. Poison is equipped with all types of biochemical weapons that infect her in different ways like depleting her health, losing abilities, stiffening her speed, maybe even changing the control scheme so you never know which ability you'll get. While Wonder Woman wins, Dr. Poison gets some of Diana's blood. She gets just enough to create her most sick and horrific creation, Genocide for the end game cliffhanger.
Also I agree with Alpha and Dr.Poison about Dr. Poison's characterization; however, I was specifically talking about her design earlier. I don't like the all-black, trench coat and mask design. I'd rather something like the 2017 movie or even something like below.
Poison Fanart.jpg
Seeing that image makes me think that they could probably have Poison be the creator of venom that Bane uses and make her more top tier in the DC-verse.
Bane's serum is a knock off of Hourman's Miraclo forumla.
A WW/Hourman cross over would be interesting with Poison turning Rick Tyler into a freak by messing with his miraclo pills so Diana and Jesse have to team up to stop them. You can even have Jesse geek out about being with Diana and asking her questions for her thesis.
Currently(or soon to be) Reading: Absolute Power, Batman/Superman: World's Finest, Birds of Prey, Green Arrow, Green Lantern, Justice Society of America, Shazam, Titans, & Wonder Woman.
Cheetah and the new Superwoman on one of the covers for the War for Earth-3 crossover.