The race to reach Novissima first I'm not so sure about. Ascendancy means they all get assimilated into a techno-organic civilization and lose what they are. Even the Librarian was questioning if that was a good idea or not when the time came to be absorbed into the Phalanx. Which seemed like the 'human' side of himself that wants to remain an individual struggling against the Machine that they have engineered into themselves that wants to become a part of a higher Machine power.
Not that the comics will ever reach that period of time but I'd think if they managed to either become the dominant species in the solar system or find a way to co-exist with humanity to the x3 point in time they'd evade/resist/eventually go to war with the Phalanx to preserve their corporeal existence.