I think some of the more cliched elements might go by the wayside, like the tribal challenge and the heart-shaped herb. Instead, a franchise created from scratch would be more likely to lean into real-world African spirituality, especially if it was created by someone who was, you know, actually African.
I also suspect it wouldn't be called Black Panther, since not only is the whole "Black hero named Black something" old-fashioned, but there are no panthers in Africa. Perhaps Ingonyama, Ingwe, or Tau.
Visually, there's an artist on Deviantart I revisit every once in a while who has a great Afrofuturist aesthetic:
https://www.deviantart.com/mshindo9/...alth-340623939
Our own Flex Hectic knows him, I believe.